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Neural crest tumor

MedGen UID:
443997
•Concept ID:
C2931189
•
Disease or Syndrome
Synonym: Neural crest-derived tumors

Professional guidelines

PubMed

Preclinical evaluation of engineered oncolytic herpes simplex virus for the treatment of neuroblastoma.
Gillory LA, Megison ML, Stewart JE, Mroczek-Musulman E, Nabers HC, Waters AM, Kelly V, Coleman JM, Markert JM, Gillespie GY, Friedman GK, Beierle EA
PLoS One 2013;8(10):e77753. Epub 2013 Oct 10 doi: 10.1371/journal.pone.0077753. PMID: 24130898Free PMC Article
The French Congenital Central Hypoventilation Syndrome Registry: general data, phenotype, and genotype.
Trang H, Dehan M, Beaufils F, Zaccaria I, Amiel J, Gaultier C; French CCHS Working Group
Chest 2005 Jan;127(1):72-9. doi: 10.1378/chest.127.1.72. PMID: 15653965

Recent clinical studies

Etiology

Variable phenotypes in congenital central hypoventilation syndrome with PHOX2B nonpolyalanine repeat mutations.
Kasi AS, Li H, Jurgensen TJ, Guglani L, Keens TG, Perez IA
J Clin Sleep Med 2021 Oct 1;17(10):2049-2055. doi: 10.5664/jcsm.9370. PMID: 33983112Free PMC Article
ROHHAD(NET) Syndrome: Systematic Review of the Clinical Timeline and Recommendations for Diagnosis and Prognosis.
Harvengt J, Gernay C, Mastouri M, Farhat N, Lebrethon MC, Seghaye MC, Bours V
J Clin Endocrinol Metab 2020 Jul 1;105(7) doi: 10.1210/clinem/dgaa247. PMID: 32407531
Neural crest-derived tumor neuroblastoma and melanoma share 1p13.2 as susceptibility locus that shows a long-range interaction with the SLC16A1 gene.
Avitabile M, Succoio M, Testori A, Cardinale A, Vaksman Z, Lasorsa VA, Cantalupo S, Esposito M, Cimmino F, Montella A, Formicola D, Koster J, Andreotti V, Ghiorzo P, Romano MF, Staibano S, Scalvenzi M, Ayala F, Hakonarson H, Corrias MV, Devoto M, Law MH, Iles MM, Brown K, Diskin S, Zambrano N, Iolascon A, Capasso M
Carcinogenesis 2020 May 14;41(3):284-295. doi: 10.1093/carcin/bgz153. PMID: 31605138Free PMC Article
Utility of Phox2b immunohistochemical stain in neural crest tumours and non-neural crest tumours in paediatric patients.
Warren M, Matsuno R, Tran H, Shimada H
Histopathology 2018 Mar;72(4):685-696. Epub 2017 Dec 21 doi: 10.1111/his.13412. PMID: 28986989
The genomic landscape of phaeochromocytoma.
Flynn A, Benn D, Clifton-Bligh R, Robinson B, Trainer AH, James P, Hogg A, Waldeck K, George J, Li J, Fox SB, Gill AJ, McArthur G, Hicks RJ, Tothill RW
J Pathol 2015 May;236(1):78-89. Epub 2015 Feb 2 doi: 10.1002/path.4503. PMID: 25545346

Diagnosis

ROHHAD(NET) Syndrome: Systematic Review of the Clinical Timeline and Recommendations for Diagnosis and Prognosis.
Harvengt J, Gernay C, Mastouri M, Farhat N, Lebrethon MC, Seghaye MC, Bours V
J Clin Endocrinol Metab 2020 Jul 1;105(7) doi: 10.1210/clinem/dgaa247. PMID: 32407531
Endocrine tumors associated with the vagus nerve.
Varoquaux A, Kebebew E, Sebag F, Wolf K, Henry JF, Pacak K, Taïeb D
Endocr Relat Cancer 2016 Sep;23(9):R371-9. Epub 2016 Jul 12 doi: 10.1530/ERC-16-0241. PMID: 27406876Free PMC Article
The genomic landscape of phaeochromocytoma.
Flynn A, Benn D, Clifton-Bligh R, Robinson B, Trainer AH, James P, Hogg A, Waldeck K, George J, Li J, Fox SB, Gill AJ, McArthur G, Hicks RJ, Tothill RW
J Pathol 2015 May;236(1):78-89. Epub 2015 Feb 2 doi: 10.1002/path.4503. PMID: 25545346
The neural crest: a versatile organ system.
Zhang D, Ighaniyan S, Stathopoulos L, Rollo B, Landman K, Hutson J, Newgreen D
Birth Defects Res C Embryo Today 2014 Sep;102(3):275-98. Epub 2014 Sep 16 doi: 10.1002/bdrc.21081. PMID: 25227568
Progress and challenges in neuroendocrine and neural crest tumours: molecular imaging and therapy.
Lucignani G, Bombardieri E
Eur J Nucl Med Mol Imaging 2009 Dec;36(12):2081-8. doi: 10.1007/s00259-009-1286-7. PMID: 19844707

Therapy

Evolution of delayed resistance to immunotherapy in a melanoma responder.
Liu D, Lin JR, Robitschek EJ, Kasumova GG, Heyde A, Shi A, Kraya A, Zhang G, Moll T, Frederick DT, Chen YA, Wang S, Schapiro D, Ho LL, Bi K, Sahu A, Mei S, Miao B, Sharova T, Alvarez-Breckenridge C, Stocking JH, Kim T, Fadden R, Lawrence D, Hoang MP, Cahill DP, Malehmir M, Nowak MA, Brastianos PK, Lian CG, Ruppin E, Izar B, Herlyn M, Van Allen EM, Nathanson K, Flaherty KT, Sullivan RJ, Kellis M, Sorger PK, Boland GM
Nat Med 2021 Jun;27(6):985-992. Epub 2021 May 3 doi: 10.1038/s41591-021-01331-8. PMID: 33941922Free PMC Article
Comparison of Primary Spinal Central and Peripheral Primitive Neuroectodermal Tumors in Clinical and Imaging Characteristics and Long-Term Outcome.
Qi W, Deng X, Liu T, Hou Y, Yang C, Wu L, Fang J, Tong X, Yang J, Xu Y
World Neurosurg 2016 Apr;88:359-369. Epub 2015 Dec 31 doi: 10.1016/j.wneu.2015.12.033. PMID: 26748171
Primitive neuroectodermal tumor of adrenal: clinical presentation and outcomes.
Dutta D, Shivaprasad KS, Das RN, Ghosh S, Chowdhury S
J Cancer Res Ther 2013 Oct-Dec;9(4):709-11. doi: 10.4103/0973-1482.126459. PMID: 24518722
p75NTR: an enhancer of fenretinide toxicity in neuroblastoma.
Ganeshan V, Ashton J, Schor NF
Cancer Chemother Pharmacol 2013 Mar;71(3):777-87. Epub 2013 Jan 13 doi: 10.1007/s00280-013-2071-7. PMID: 23314735Free PMC Article
A neurologist's approach to neuroblastoma.
Schor NF
J Child Neurol 1992 Jan;7(1):93-8. doi: 10.1177/088307389200700116. PMID: 1313058

Prognosis

Evolution of delayed resistance to immunotherapy in a melanoma responder.
Liu D, Lin JR, Robitschek EJ, Kasumova GG, Heyde A, Shi A, Kraya A, Zhang G, Moll T, Frederick DT, Chen YA, Wang S, Schapiro D, Ho LL, Bi K, Sahu A, Mei S, Miao B, Sharova T, Alvarez-Breckenridge C, Stocking JH, Kim T, Fadden R, Lawrence D, Hoang MP, Cahill DP, Malehmir M, Nowak MA, Brastianos PK, Lian CG, Ruppin E, Izar B, Herlyn M, Van Allen EM, Nathanson K, Flaherty KT, Sullivan RJ, Kellis M, Sorger PK, Boland GM
Nat Med 2021 Jun;27(6):985-992. Epub 2021 May 3 doi: 10.1038/s41591-021-01331-8. PMID: 33941922Free PMC Article
ROHHAD(NET) Syndrome: Systematic Review of the Clinical Timeline and Recommendations for Diagnosis and Prognosis.
Harvengt J, Gernay C, Mastouri M, Farhat N, Lebrethon MC, Seghaye MC, Bours V
J Clin Endocrinol Metab 2020 Jul 1;105(7) doi: 10.1210/clinem/dgaa247. PMID: 32407531
Metastatic Primitive Neuroectodermal Tumor of the Prostate: A Case Report and Review of the Literature.
Kord Valeshabad A, Choi P, Dababo N, Shamim E, Alsadi A, Xie KL
Clin Genitourin Cancer 2018 Apr;16(2):e343-e347. Epub 2017 Nov 7 doi: 10.1016/j.clgc.2017.10.023. PMID: 29239847
Hormone-secreting large adrenal ganglioneuroma in an adult patient: a case report and review of literature.
Erem C, Fidan M, Civan N, Cobanoglu U, Kangul F, Nuhoglu I, Alhan E
Blood Press 2014 Feb;23(1):64-9. Epub 2013 May 27 doi: 10.3109/08037051.2013.796103. PMID: 23705630
A neurologist's approach to neuroblastoma.
Schor NF
J Child Neurol 1992 Jan;7(1):93-8. doi: 10.1177/088307389200700116. PMID: 1313058

Clinical prediction guides

Evolution of physiologic and autonomic phenotype in rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation over a decade from age at diagnosis.
Khaytin I, Stewart TM, Zelko FA, Kee MAL, Osipoff JN, Slattery SM, Weese-Mayer DE
J Clin Sleep Med 2022 Mar 1;18(3):937-944. doi: 10.5664/jcsm.9740. PMID: 34694990Free PMC Article
A population-based analysis of clinical features and lymph node dissection in head and neck malignant neurogenic tumors.
Fang X, Wang S, Zhao J, Zhang Y, Zhang J, Li Y, Li X, Tai J, Ni X
BMC Cancer 2021 May 24;21(1):598. doi: 10.1186/s12885-021-08307-4. PMID: 34030648Free PMC Article
Low DLG2 gene expression, a link between 11q-deleted and MYCN-amplified neuroblastoma, causes forced cell cycle progression, and predicts poor patient survival.
Keane S, Améen S, Lindlöf A, Ejeskär K
Cell Commun Signal 2020 Apr 20;18(1):65. doi: 10.1186/s12964-020-00553-6. PMID: 32312269Free PMC Article
Neural crest-derived tumor neuroblastoma and melanoma share 1p13.2 as susceptibility locus that shows a long-range interaction with the SLC16A1 gene.
Avitabile M, Succoio M, Testori A, Cardinale A, Vaksman Z, Lasorsa VA, Cantalupo S, Esposito M, Cimmino F, Montella A, Formicola D, Koster J, Andreotti V, Ghiorzo P, Romano MF, Staibano S, Scalvenzi M, Ayala F, Hakonarson H, Corrias MV, Devoto M, Law MH, Iles MM, Brown K, Diskin S, Zambrano N, Iolascon A, Capasso M
Carcinogenesis 2020 May 14;41(3):284-295. doi: 10.1093/carcin/bgz153. PMID: 31605138Free PMC Article
Pax7 lineage contributions to the mammalian neural crest.
Murdoch B, DelConte C, García-Castro MI
PLoS One 2012;7(7):e41089. Epub 2012 Jul 27 doi: 10.1371/journal.pone.0041089. PMID: 22848431Free PMC Article

Recent systematic reviews

ROHHAD(NET) Syndrome: Systematic Review of the Clinical Timeline and Recommendations for Diagnosis and Prognosis.
Harvengt J, Gernay C, Mastouri M, Farhat N, Lebrethon MC, Seghaye MC, Bours V
J Clin Endocrinol Metab 2020 Jul 1;105(7) doi: 10.1210/clinem/dgaa247. PMID: 32407531

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